Article
The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies.
PLoS medicine - 15 Jun 2010
Rodger Marc A, Betancourt Marisol T, Clark Peter, Lindqvist Pelle G, Dizon-Townson Donna, Said Joanne, Seligsohn Uri, Carrier Marc, Salomon Ophira, Greer Ian A
Abstract excerpt
BACKGROUND: Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias. Retrospective studies variably suggest a link between maternal FVL/PGM and placenta-mediated pregnancy complications including pregnancy loss, small for gestational age, pre-eclampsia and placental abruption. Prospective cohort studies provide a superior methodologic design but require larger sample sizes to...
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