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Article

Antisense inhibition of c-myc expression reveals common and distinct mechanisms of growth inhibition by TGF beta and TNF alpha.

Journal of cellular biochemistry - 1 Feb 1991

Robinson-Benion C, Salhany K E, Hann S R, Holt J T

Abstract excerpt

Downregulation of the c-myc gene in HL-60 cells is associated with growth inhibition and induction of differentiation. Previous studies have reported that the growth inhibitors TGF beta and TNF alpha downregulate c-myc mRNA levels, suggesting the possibility that these agents may exert some of th...

Topics

Cell Differentiation
Cell Division
Depression, Chemical
Drug Interactions
Gene Expression Regulation, Neoplastic
Humans
Leukemia, Promyelocytic, Acute
Male
Phenotype
Proto-Oncogene Proteins c-myc
RNA, Antisense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transforming Growth Factor beta

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 2055946
DOI: 10.1002/jcb.240450210

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2055946-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Antisense inhibition of c-myc expression reveals common and distinct mechanisms of growth inhibition by TGF beta and TNF alpha.PMID 2055946Read ↗

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Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.Semantic proximity Read ↗

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