Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antisense inhibition of c-myc expression reveals common and distinct mechanisms of growth inhibition by TGF beta and TNF alpha.

Journal of cellular biochemistry - 1 Feb 1991

Robinson-Benion C, Salhany K E, Hann S R, Holt J T

Abstract excerpt

Downregulation of the c-myc gene in HL-60 cells is associated with growth inhibition and induction of differentiation. Previous studies have reported that the growth inhibitors TGF beta and TNF alpha downregulate c-myc mRNA levels, suggesting the possibility that these agents may exert some of their phenotypic effects via c-myc downregulation. Our study demonstrates that although both growth inhibitors produce a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to TNF gene

Share to Phenotype

Share to Transforming Growth Factor beta

Share to Tumor Cells, Cultured

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 2055946
DOI: 10.1002/jcb.240450210

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Antisense inhibition of c-myc expression reveals common and distinct mechanisms of growth inhibition by TGF beta and TNF alpha.PMID 2055946Read ↗

The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growthSemantic proximity Read ↗

Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells.Semantic proximity Read ↗

Antisense suppression of N-myc expression inhibits the transdifferentiation of neuroectoderm tumor cell lines.Semantic proximity Read ↗

A role for transcriptional repression of p21 <sup>CIP1</sup> by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrestSemantic proximity Read ↗

Constitutive expression of exogenous myc in myelomonocytic cells: acquisition of a more transformed phenotype and inhibition of differentiation induction.Semantic proximity Read ↗

Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells.Semantic proximity Read ↗

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expressionSemantic proximity Read ↗

Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.