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Article

Neurones express glutamine synthetase when deprived of glutamine or interaction with astrocytes.

Journal of neurochemistry - 1 Sept 2010

Fernandes Samantha P, Dringen Ralf, Lawen Alfons, Robinson Stephen R

Abstract excerpt

Glutamine synthetase (GS) forms glutamine by catalyzing the ATP-dependent amidation of glutamate. In healthy brains, GS is restricted to astrocytes but in Alzheimer's disease and cell culture, GS has been detected in neurones. The present study demonstrates the expression of functional GS in cultured cerebellar granule cells and investigates conditions required to reduce this expression. Cerebellar granule cells...

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Identifiers

PMID: 20557426
DOI: 10.1111/j.1471-4159.2010.06869.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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