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Article

Imprinting of RB1 (the new kid on the block)

15 Jun 2010

Abstract excerpt

Recent data have revealed that the paradigmatic tumour suppressor gene RB1 on chromosome 13 is preferentially expressed from the maternal allele. Imprinted expression of RB1 is linked to a differentially methylated CpG island in intron 2 of this gene (CpG 85). On the paternal chromosome, CpG 85 is unmethylated and acts as a weak promoter of an alternative RB1 transcript. Paternal mRNA levels are probably reduced...

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PMID: 20551090
DOI: 10.1093/bfgp/elq014

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