Article
SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility.
Cancer - 15 Sept 2010
Ju Hyoungseok, Lim Byungho, Kim Minjin, Noh Seung-Moo, Kim Woo Ho, Ihm Chunhwa, Choi Bo Youl, Kim Yong Sung, Kang Changwon
Abstract excerpt
BACKGROUND: A primary inhibitor of plasminogen activators, SERPINE1 (serpin peptidase inhibitor 1, clade E, member 1, also known as plasminogen activator inhibitor type 1), is an important regulator in tumorigenesis and is highly expressed in many cancers. METHODS: Five tag single nucleotide polymorphisms (SNPs) and 1 insertion polymorphism within SERPINE1 were genotyped in 1101 unrelated Korean individuals (a...
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