Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling

30 Apr 2015

Abstract excerpt

INTRODUCTION: Human mesenchymal stem cells (hMSCs) reside in a perivascular niche of the body, suggesting that they interact closely with vascular endothelial cells (ECs) through cell-cell interaction or paracrine signaling to maintain cell functions. Endothelin-1 (ET1) is a paracrine factor mainly secreted by ECs. We thus hypothesize that ECs can regulate cellular activities of hMSCs and direct their stem cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Congenital heart defects research
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25998005
DOI: 10.1186/s13287-015-0065-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signalingPMID 25998005Read ↗

Regulation of Mesenchymal Stem Cell Activity by Endothelial CellsSemantic proximity Read ↗

VEGF secreted by mesenchymal stem cells mediates the differentiation of endothelial progenitor cells into endothelial cells via paracrine mechanismsSemantic proximity Read ↗

Conversion of vascular endothelial cells into multipotent stem-like cells.Semantic proximity Read ↗

Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype.Semantic proximity Read ↗

A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone BiologySemantic proximity Read ↗

The therapeutic potential of targeting the endothelial-to-mesenchymal transitionSemantic proximity Read ↗

Endothelial origin of mesenchymal stem cellsSemantic proximity Read ↗

The role of endothelial-mesenchymal transition in heterotopic ossificationSemantic proximity Read ↗

Communication between endothelial cells and osteoblasts in regulation of bone homeostasis: Notch playersSemantic proximity Read ↗

Endothelial Cells Promote Osteogenesis by Establishing a Functional and Metabolic Coupling With Human Mesenchymal Stem CellsSemantic proximity Read ↗

Molecular Profile and Partial Functional Analysis of Novel Endothelial Cell‐Derived Growth Factors that Regulate HematopoiesisSemantic proximity Read ↗

Transition of mesenchymal stem/stromal cells to endothelial cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.