Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010

Murugaiyan Gopal, Mittal Akanksha, Weiner Howard L

Abstract excerpt

Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to CD4-Positive T-Lymphocytes
Share to Coculture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Interferon-gamma

Share to Interleukin-17

Share to Osteopontin

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 20534530
DOI: 10.1073/pnas.1002099107
PMCID: PMC2895126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20534530-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.PMID 20534530Read ↗

Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype.Semantic proximity Read ↗

Interleukin-27 in T Cell ImmunitySemantic proximity Read ↗

Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T CellsSemantic proximity Read ↗

IL‐27 controls the development of inducible regulatory T cells and Th17 cells <i>via</i> differential effects on STAT1Semantic proximity Read ↗

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.Semantic proximity Read ↗

Induction of IL-17+ T Cell Trafficking and Development by IFN-γ: Mechanism and Pathological Relevance in PsoriasisSemantic proximity Read ↗

Immunoregulatory effects of interferon-β in suppression of Th17 cells.Semantic proximity Read ↗

IL-27 Regulated CD4+IL-10+ T Cells in Experimental Sjögren Syndrome.Semantic proximity Read ↗

Interleukin-27: Biological Properties and Clinical ApplicationSemantic proximity Read ↗

Interleukin-26: An IL-10-related cytokine produced by Th17 cellsSemantic proximity Read ↗

TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunitySemantic proximity Read ↗

Differential role of NF-κB, ERK1/2 and AP-1 in modulating the immunoregulatory functions of bone marrow-derived dendritic cells from NOD mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.