Molecular basis of mitochondrial DNA disease.

doi:10.1007/BF00763099

Back to search

Article

Molecular basis of mitochondrial DNA disease.

Journal of bioenergetics and biomembranes - 1 Jun 1994

Brown M D, Wallace D C

Abstract excerpt

Mitochondrial ATP production via oxidative phosphorylation (OXPHOS) is essential for normal function and maintenance of human organ systems. Since OXPHOS biogenesis depends on both nuclear- and mitochondrial-encoded gene products, mutations in both genomes can result in impaired electron transpor...

Topics

DNA, Mitochondrial
Genotype
Humans
Metabolic Diseases
Mitochondria
Mitochondrial Myopathies
Mutation
Optic Atrophies, Hereditary
Oxidative Phosphorylation
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.