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Article

Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis.

Pancreas - 1 Oct 2010

Baumgart Mario, Werther Meike, Bockholt Anke, Scheurer Maria, Rüschoff Josef, Dietmaier Wolfgang, Ghadimi B Michael, Heinmöller Ernst

Abstract excerpt

OBJECTIVE: Chronic pancreatitis (CP) is a predisposing disease for pancreatic carcinoma (PC), however, precise molecular mechanisms of cancer development in the background of CP are ill defined. METHODS: A total of 443 laser-microdissected pancreatic intraepithelial neoplasias (PanINs), acinar-ductal metaplasia (ADM), and normal ducts from 21 patients with CP were analyzed for loss of heterozygosity (LOH) and...

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Source

Identifiers

PMID: 20531246
DOI: 10.1097/MPA.0b013e3181dc62f6

Genes

ADM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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