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Article

BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications.

The American journal of pathology - 1 May 2000

Goggins M, Hruban R H, Kern S E

Abstract excerpt

Patients harboring germline BRCA2 mutations are at an increased risk of developing pancreatic cancer. We investigated the prevalence of biallelic inactivation of BRCA2 in the presumed precursors to invasive pancreatic ductal carcinomas, pancreatic intraepithelial neoplasia (PanIN). Surgical resec...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10793087
DOI: 10.1016/S0002-9440(10)65047-X
PMCID: PMC1876938

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10793087-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications.PMID 10793087Read ↗

Molecular genetics of pancreatic intraepithelial neoplasia.Semantic proximity Read ↗

Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.Semantic proximity Read ↗

Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis.Semantic proximity Read ↗

Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis.Semantic proximity Read ↗

Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer.Semantic proximity Read ↗

Genetic progression and divergence in pancreatic carcinoma.Semantic proximity Read ↗

Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.Semantic proximity Read ↗

High Prevalence of BRCA1 and BRCA2 Germline Mutations with Loss of Heterozygosity in a Series of Resected Pancreatic Adenocarcinoma and Other Neoplastic LesionsSemantic proximity Read ↗

Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.Semantic proximity Read ↗

Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.Semantic proximity Read ↗

Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasiaSemantic proximity Read ↗

Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status.Semantic proximity Read ↗

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