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Article

Prion protein expression and processing in human mononuclear cells: the impact of the codon 129 prion gene polymorphism.

PloS one - 4 Jun 2009

Segarra Christiane, Lehmann Sylvain, Coste Joliette

Abstract excerpt

BACKGROUND: So far, all clinical cases of new variant Creutzfeldt-Jakob disease (vCJD), thought to result from the Bovine Spongiform Encephalopathy (BSE) prion agent, have shown Methionine-Methionine (M/M) homozygosity at the M129V polymorphism of the PRNP gene. Although established, this relationship is still not understood. In both vCJD and experimental BSE models prion agents do reach the bloodstream, raising...

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Identifiers

PMID: 19495414
DOI: 10.1371/journal.pone.0005796
PMCID: PMC2686158

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prion protein expression and processing in human mononuclear cells: the impact of the codon 129 prion gene polymorphism.PMID 19495414Read ↗

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