Article
Evaluating differences in linkage disequilibrium between populations.
Annals of human genetics - 1 May 2010
Hrafnkelsson Birgir, Helgason Agnar, Jonsson Gudbjorn F, Gudbjartsson Daniel F, Jonsson Thorlakur, Thorvaldsson Sverrir, Stefansson Hreinn, Steinthorsdottir Valgerdur, Vidarsdottir Nanna, Middleton Derek, Petersen Henning S, Martinez Conrado, Snaedal Jon, Jonsson Palmi V, Bjornsson Sigurbjorn, Gulcher Jeffrey R, Stefansson Kari
Abstract excerpt
We propose two methods to evaluate the statistical significance of differences in linkage disequilibrium (LD) between populations, where LD is measured by the standardised parameter D'. The first method is based on bootstrapping individuals within populations in order to test LD differences for each pair of loci. Using this approach we propose a solution to the problem of testing multiple locus-pairs by means of...
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