Article
Exploiting linkage disequilibrium in population isolates.
Genetic epidemiology - 1 Jan 2001
Culverhouse R, Lin J, Liu K Y, Suarez B K
Abstract excerpt
A comparison of haplotype frequencies between unrelated cases and controls from population isolates identifies a strong signal for the presence/absence of the discrete phenotype in an interval on chromosome 6 bounded by markers 34 and 35. We define a dissimilarity index, D, which is sensitive to differences in allele distributions and differences in the patterns of linkage disequilibrium between cases and...
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