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Article

Self-assembled nucleic acid nanoparticles capable of controlled disassembly in response to a single nucleotide mismatch.

Biomacromolecules - 12 Jul 2010

Kim Jandi, Im Cho-Ah, Jung Yongchul, Qazi Altaf, Shin Jong-Shik

Abstract excerpt

We have demonstrated the self-assembled DNA nanoparticles capable of controlled disassembly in response to a single nucleotide change (SNC) in a target nucleic acid. The DNA nanoparticles (avg diameter=51+/-22 nm) were constructed by joining two types of streptavidin-DNA conjugates with 2 molar equiv of a linker strand that carries complementary sequences to both conjugates. Nanoparticle disassembly triggered by...

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PMID: 20527811
DOI: 10.1021/bm100368d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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