Article
Oligothiophene-5-labeled deoxyuridines for the detection of single nucleotide polymorphisms.
Bioconjugate chemistry - 1 Jan 2008
Capobianco Massimo L, Cazzato Antonella, Alesi Silvia, Barbarella Giovanna
Abstract excerpt
We report the synthesis of four oligothiophene-5-labeled deoxyuridines. These modified fluorescent nucleosides have been incorporated into oligodeoxynucleotides designed to be used as probes to discriminate, through changes in fluorescence emission, between hybridization with a perfectly complementary strand and that with a single nucleotide mismatch facing the modified uridines. Upon hybridization, remarkable...
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