Article
No association between genetic or epigenetic variation in insulin growth factors and antipsychotic-induced metabolic disturbances in a cross-sectional sample.
Pharmacogenomics - 1 May 2014
Moons Tim, De Hert Marc, Kenis Gunther, Viechtbauer Wolfgang, van Os Jim, Gohlke Henning, Claes Stephan, van Winkel Ruud
Abstract excerpt
AIM: Second-generation antipsychotics (SGA) are known to induce metabolic disturbances. Genetic pathways, such as the IGF pathway could be associated with increased metabolic syndrome (MetS). Additionally, IGF2 methylation varies as a function of environmental influences and is associated with schizophrenia and MetS. The current study aims to evaluate whether genetic and epigenetic variation in genes of the IGF...
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