Article
A promising alternative anti-HBV agent: the targeted ribonuclease.
International journal of molecular medicine - 1 Jul 2010
Li Yinghui, Zhao Ya, Liu Jun, Huang Yuxiao, Liu Zhongxiang, Xue Caifang
Abstract excerpt
HBV-targeted ribonuclease (TR) is a fusion of HBV core protein (HBVc) and human eosinophil-derived neurotoxin (hEDN). Introduction of TR by transfection or transduction into HepG2.2.15 cells (a cell model of HBV infection) revealed that it significantly reduces serological markers of HBV replicat...
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