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Article

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.

International journal of oncology - 1 Jul 2010

Farias Lucyana Conceição, Fraga Carlos Alberto De Carvalho, De Oliveira Marcos Vinícius Macedo, Silva Thiago Fonseca, Marques-Silva Luciano, Moreira Paula Rocha, De-Paula Alfredo Maurício Batista, Gomez Ricardo Santiago, Guimarães André Luiz Sena

Abstract excerpt

De novo DNA methylation is a relevant epigenetic mechanism, which represses gene transcription and commonly inactivates tumor suppressor genes in carcinogenesis. A single nucleotide polymorphism of DNMT3B, C46359T (-149C-->T) was reported to modulate individual's susceptibility to cancer. We investigated the role of this polymorphic variant regarding the methylation status of the p16CDKN2A gene in young and older...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20514408
DOI: 10.3892/ijo_00000664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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