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Article

Role of alpha-actinin-3 in contractile properties of human single muscle fibers: a case series study in paraplegics.

PloS one - 1 Jan 2012

Broos Siacia, Malisoux Laurent, Theisen Daniel, Francaux Marc, Deldicque Louise, Thomis Martine A

Abstract excerpt

A common nonsense polymorphism in the ACTN3 gene results in the absence of α-actinin-3 in XX individuals. The wild type allele has been associated with power athlete status and an increased force output in numeral studies, though the mechanisms by which these effects occur are unclear. Recent findings in the Actn3(-/-) (KO) mouse suggest a shift towards 'slow' metabolic and contractile characteristics of fast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Major Histocompatibility Complex

Share to Muscle Fibers, Fast-Twitch

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 23145141
DOI: 10.1371/journal.pone.0049281
PMCID: PMC3493539

Genes

ACTN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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