Article
SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region.
Human mutation - 1 Jul 2010
Melum Espen, May Sandra, Schilhabel Markus B, Thomsen Ingo, Karlsen Tom H, Rosenstiel Philip, Schreiber Stefan, Franke Andre
Abstract excerpt
A potentially important application of second generation sequencing technologies is to identify disease-associated variation. For comparison of the performance in SNP detection, the Crohn's disease (CD)-associated NOD2 gene was subjected to targeted resequencing using two different second-generation sequencing technologies. Eleven CD patients were selected based on their haplotype background at the NOD2 locus....
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