Article
Validation of dot blot hybridization and denaturing high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studies.
BMC genetics - 26 May 2010
Rabachini Tatiana, Trottier Helen, Franco Eduardo L, Villa Luisa L
Abstract excerpt
BACKGROUND: Mutations in TP53 are common events during carcinogenesis. In addition to gene mutations, several reports have focused on TP53 polymorphisms as risk factors for malignant disease. Many studies have highlighted that the status of the TP53 codon 72 polymorphism could influence cancer susceptibility. However, the results have been inconsistent and various methodological features can contribute to...
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