Article
Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Sylla B S, Hung S C, Davidson D M, Hatzivassiliou E, Malinin N L, Wallach D, Gilmore T D, Kieff E, Mosialos G
Abstract excerpt
The Epstein-Barr virus oncoprotein latent infection membrane protein 1 (LMP1) is a constitutively aggregated pseudo-tumor necrosis factor receptor (TNFR) that activates transcription factor NF-kappaB through two sites in its C-terminal cytoplasmic domain. One site is similar to activated TNFRII i...
Topics
- Animals
- Binding Sites
- Cell Line
- Herpesvirus 4, Human
- Humans
- I-kappa B Kinase
- In Vitro Techniques
- Mutation
- NF-kappa B
- Phosphorylation
- Protein Serine-Threonine Kinases
- Rabbits
- Reticulocytes