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Article

In vitro system for modeling influenza A virus resistance under drug pressure.

Antimicrobial agents and chemotherapy - 1 Aug 2010

Brown Ashley N, McSharry James J, Weng Qingmei, Driebe Elizabeth M, Engelthaler David M, Sheff Kelly, Keim Paul S, Nguyen Jack, Drusano George L

Abstract excerpt

One of the biggest challenges in the effort to treat and contain influenza A virus infections is the emergence of resistance during treatment. It is well documented that resistance to amantadine arises rapidly during the course of treatment due to mutations in the gene coding for the M2 protein. To address this problem, it is critical to develop experimental systems that can accurately model the selection of...

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Identifiers

PMID: 20498316
DOI: 10.1128/AAC.01385-09
PMCID: PMC2916361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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