Article
CCAAT/enhancer-binding protein alpha (CEBPA) polymorphisms and mutations in healthy individuals and in patients with peripheral artery disease, ischaemic heart disease and hyperlipidaemia.
Folia biologica - 1 Jan 2010
Fuchs O, Kostecka A, Provazníková D, Krásná B, Kotlín R, Stanková M, Kobylka P, Dostálová G, Zeman M, Chochola M
Abstract excerpt
The CCAAT/enhancer-binding protein alpha, encoded by the intronless CEBPA gene, is a transcription factor that induces expression of genes involved in differentiation of granulocytes, monocytes, adipocytes and hepatocytes. Both mono- and bi-allelic CEBPA mutations were detected in acute myeloid leukaemia and myelodysplastic syndrome. In this study we also identified CEBPA mutations in healthy individuals and in...
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