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Article

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.

The Journal of biological chemistry - 30 Jul 2010

Li Xiaofeng, Zhang Rong, Zhang Haifeng, He Yun, Ji Weidong, Min Wang, Boggon Titus J

Abstract excerpt

CCM3 mutations are associated with cerebral cavernous malformation (CCM), a disease affecting 0.1-0.5% of the human population. CCM3 (PDCD10, TFAR15) is thought to form a CCM complex with CCM1 and CCM2; however, the molecular basis for these interactions is not known. We have determined the 2.5 A...

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Share to Apoptosis Regulatory Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemangioma, Cavernous, Central Nervous System

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Source

Open in PubMed Open full text

Identifiers

PMID: 20489202
DOI: 10.1074/jbc.M110.128470
PMCID: PMC2911348

Genes

CCM2
PDCD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20489202-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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