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Article

Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos.

PloS one - 12 May 2010

Zhang Yuyan, Yang Shaoli, Liu Ming, Song Chunxia, Wu Ning, Ling Peixue, Chu Edward, Lin Xiukun

Abstract excerpt

Thymidylate synthase (TS), which catalyzes the de novo synthesis of dUMP, is an important target for cancer therapy. In this report, the effects of 5-fluorouracil (5-FU) and ZD1694 on the regulation of TS gene expression were evaluated in zebrafish embryos. Our results revealed that the expression of TS was increased by about six-fold when embryos were treated with 1.0 microM 5-FU and there was a greater than...

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Identifiers

PMID: 20485548
DOI: 10.1371/journal.pone.0010618
PMCID: PMC2868900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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