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Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors

16 Oct 2014

Abstract excerpt

Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to...

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PMID: 25320321
DOI: 10.1128/jvi.02328-14

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