Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Comprehensive Study of the Retinal Phenotype of Rpe65-Deficient Dogs.

Cells - 9 Jan 2021

Annear Matthew J, Mowat Freya M, Occelli Laurence M, Smith Alexander J, Curran Paul G, Bainbridge James W, Ali Robin R, Petersen-Jones Simon M

Abstract excerpt

The Rpe65-deficient dog has been important for development of translational therapies of Leber congenital amaurosis type 2 (LCA2). The purpose of this study was to provide a comprehensive report of the natural history of retinal changes in this dog model. Rpe65-deficient dogs from 2 months to 10 years of age were assessed by fundus imaging, electroretinography (ERG) and vision testing (VT). Changes in retinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Ocular
Share to cis-trans-Isomerases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electroretinography

Share to Fundus Oculi

Share to Retina

Share to Retinal Pigment Epithelium

Share to Tomography, Optical Coherence

Share to Vision, Ocular

Source

Open in PubMed Open full text

Identifiers

PMID: 33435495
DOI: 10.3390/cells10010115
PMCID: PMC7827248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Comprehensive Study of the Retinal Phenotype of Rpe65-Deficient Dogs.PMID 33435495Read ↗

Retinal disease in Rpe65-deficient mice: comparison to human leber congenital amaurosis due to RPE65 mutations.Semantic proximity Read ↗

Long-term effect of gene therapy on Leber's congenital amaurosis.Semantic proximity Read ↗

A novel form of progressive retinal atrophy in Swedish vallhund dogs.Semantic proximity Read ↗

Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement.Semantic proximity Read ↗

Defining the residual vision in leber congenital amaurosis caused by RPE65 mutations.Semantic proximity Read ↗

Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis.Semantic proximity Read ↗

Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success.Semantic proximity Read ↗

Long-Term Structural Outcomes of Late-Stage RPE65 Gene TherapySemantic proximity Read ↗

Successful Gene Therapy in Older Rpe65-Deficient Dogs Following Subretinal Injection of an Adeno-Associated Vector Expressing <i>RPE65</i>Semantic proximity Read ↗

Advances in the molecular understanding of canine retinal diseases.Semantic proximity Read ↗

Photoreceptor layer topography in children with leber congenital amaurosis caused by RPE65 mutations.Semantic proximity Read ↗

Human cone photoreceptor dependence on RPE65 isomeraseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.