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Article

A Comprehensive Study of the Retinal Phenotype of Rpe65-Deficient Dogs.

Cells - 9 Jan 2021

Annear Matthew J, Mowat Freya M, Occelli Laurence M, Smith Alexander J, Curran Paul G, Bainbridge James W, Ali Robin R, Petersen-Jones Simon M

Abstract excerpt

The Rpe65-deficient dog has been important for development of translational therapies of Leber congenital amaurosis type 2 (LCA2). The purpose of this study was to provide a comprehensive report of the natural history of retinal changes in this dog model. Rpe65-deficient dogs from 2 months to 10 years of age were assessed by fundus imaging, electroretinography (ERG) and vision testing (VT). Changes in retinal...

Topics

Adaptation, Ocular
Aging
Animals
Dogs
Electroretinography
Fundus Oculi
Light
Phenotype
Retina
Retinal Pigment Epithelium
Tomography, Optical Coherence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vision, Ocular

cis-trans-Isomerases

Source

Open in PubMed Open full text

Identifiers

PMID: 33435495
DOI: 10.3390/cells10010115
PMCID: PMC7827248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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