Article
NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations.
Molecular cancer - 19 May 2010
Fu Yi-Ping, Edvardsen Hege, Kaushiva Alpana, Arhancet Juan P, Howe Tiffany M, Kohaar Indu, Porter-Gill Patricia, Shah Anushi, Landmark-Høyvik Hege, Fosså Sophie D, Ambs Stefan, Naume Bjørn, Børresen-Dale Anne-Lise, Kristensen Vessela N, Prokunina-Olsson Ludmila
Abstract excerpt
BACKGROUND: A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as a novel genetic risk factor for breast cancer, and this association was stronger in patients with estrogen receptor (ER)+ versus ER- cancer. RESULTS: We found association between SNP rs11249433 and expression of the NOTCH2 gene located in the 1p11.2 region. Examined in...
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