Article
Human Epidermal Growth Factor Receptor-2 gene polymorphism and breast cancer risk in women from the Northeastern region of Brazil.
Clinics (Sao Paulo, Brazil) - 1 Jan 2020
Escórcio-Dourado Carla Solange, Alves-Ribeiro Francisco Adelton, Lima-Dourado Jose Charles, Dos Santos Alesse Ribeiro, de Oliveira Pereira Renato, Tavares Cleciton Braga, Silva Vladimir Costa, Costa Pedro Vitor Lopes, Soares-Júnior José Maria, da Silva Benedito Borges
Abstract excerpt
OBJECTIVES: In the Human Epidermal Growth Factor Receptor-2 (HER2) rs1136201 variant, the presence of the G allele may promote cellular alterations and increase breast cancer risk, in addition to enhanced cellular proliferation, tumor aggressiveness, and metastases. The aim of this study was to investigate the presence of the single-nucleotide polymorphism (SNP) variant, rs1136201, within the HER2 gene in women...
Read the complete abstract on PubMed