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Article

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

1 Jan 2010

Abstract excerpt

BACKGROUND: Klotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO was reported to function as a secreted Wnt antagonist and as a tumor suppressor. Epigenetic gene silencing of secreted Wnt antagonists is considered a common event in a wide range of human malignancies. Abnormal activation of the canonical Wnt pathway...

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PMID: 20482749
DOI: 10.1186/1476-4598-9-109

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