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Article

Directed screen of Francisella novicida virulence determinants using Drosophila melanogaster.

Infection and immunity - 1 Jul 2010

Ahlund Monika K, Rydén Patrik, Sjöstedt Anders, Stöven Svenja

Abstract excerpt

Francisella tularensis is a highly virulent, facultative intracellular human pathogen whose virulence mechanisms are not well understood. Occasional outbreaks of tularemia and the potential use of F. tularensis as a bioterrorist agent warrant better knowledge about the pathogenicity of this bacterium. Thus far, genome-wide in vivo screens for virulence factors have been performed in mice, all however restricted...

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Identifiers

PMID: 20479082
DOI: 10.1128/IAI.00146-10
PMCID: PMC2897386

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Source receipt: pubmed, retrieved 7 Sept 2026.

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