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Article

pRB immunostaining in the differential diagnosis between pleomorphic xanthoastrocytoma and glioblastoma with giant cells.

Histopathology - 1 Nov 2022

Barresi Valeria, Simbolo Michele, Ciaparrone Chiara, Pedron Serena, Mafficini Andrea, Scarpa Aldo

Abstract excerpt

AIMS: Pleomorphic xanthoastrocytoma (PXA) is a rare circumscribed glioma, characterized by frequent BRAF p. V600E mutation, and classified as grade 2 or 3. Owing to overlapping clinical-pathological features, the histological distinction from glioblastoma (GBM) with giant cells (GCs) is challenging. Based on the high frequency of TP53 and RB1 alterations in the latter, this study aimed to assess the value of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35945679
DOI: 10.1111/his.14768
PMCID: PMC9804328

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