Epigenetic Regulation of Tumor Suppressors by<i>Helicobacter pylori</i>Enhances EBV-Induced Proliferation of Gastric Epithelial Cells

Abstract excerpt

ABSTRACT Helicobacter pylori and Epstein-Barr virus (EBV) are two well-known contributors to cancer and can establish lifelong persistent infection in the host. This leads to chronic inflammation, which also contributes to development of cancer. Association with H. pylori increases the risk of gastric carcinoma, and coexistence with EBV enhances proliferation of infected cells. Further, H. pylori -EBV coinfection...

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