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Article

Computational protein design: validation and possible relevance as a tool for homology searching and fold recognition.

PloS one - 5 May 2010

Schmidt Am Busch Marcel, Sedano Audrey, Simonson Thomas

Abstract excerpt

BACKGROUND: Protein fold recognition usually relies on a statistical model of each fold; each model is constructed from an ensemble of natural sequences belonging to that fold. A complementary strategy may be to employ sequence ensembles produced by computational protein design. Designed sequences can be more diverse than natural sequences, possibly avoiding some limitations of experimental databases....

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Identifiers

PMID: 20463972
DOI: 10.1371/journal.pone.0010410
PMCID: PMC2864755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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