Article
Innate immunity in human embryonic stem cells: comparison with adult human endothelial cells.
PloS one - 5 May 2010
Földes Gábor, Liu Alexander, Badiger Rekha, Paul-Clark Mark, Moreno Laura, Lendvai Zsuzsanna, Wright Jamie S, Ali Nadire N, Harding Sian E, Mitchell Jane A
Abstract excerpt
Treatment of human disease with human embryonic stem cell (hESC)-derived cells is now close to reality, but little is known of their responses to physiological and pathological insult. The ability of cells to respond via activation of Toll like receptors (TLR) is critical in innate immune sensing in most tissues, but also extends to more general danger sensing, e.g. of oxidative stress, in cardiomyocytes. We used...
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