Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts.

doi:10.1093/cvr/cvaa028

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Article

Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts.

Cardiovascular research - 1 Jan 2021

Lima Correa Bruna, El Harane Nadia, Gomez Ingrid, Rachid Hocine Hocine, Vilar José, Desgres Manon, Bellamy Valérie, Keirththana Kamaleswaran, Guillas Chloé, Perotto Maria, Pidial Laetitia, Alayrac Paul, Tran Thi, Tan Sisareuth, Hamada Thomas, Charron Dominique, Brisson Alain, Renault Nisa K, Al-Daccak Reem, Menasché Philippe, Silvestre Jean-Sébastien

Abstract excerpt

AIMS: The cardioprotective effects of human induced pluripotent stem cell-derived cardiovascular progenitor cells (CPC) are largely mediated by the paracrine release of extracellular vesicles (EV). We aimed to assess the immunological behaviour of EV-CPC, which is a prerequisite for their clinical translation. METHODS AND RESULTS: Flow cytometry demonstrated that EV-CPC expressed very low levels of immune...

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PMID: 32049348
DOI: 10.1093/cvr/cvaa028

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