Article
DRD2/ANKK1 polymorphism modulates the effect of ventral striatal activation on working memory performance.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2014
Nymberg Charlotte, Banaschewski Tobias, Bokde Arun L W, Büchel Christian, Conrod Patricia, Flor Herta, Frouin Vincent, Garavan Hugh, Gowland P, Heinz Andreas, Ittermann Bernd, Mann Karl, Martinot Jean-Luc, Nees Frauke, Paus Tomas, Pausova Zdenka, Rietschel Marcella, Robbins Trevor W, Smolka Michael N, Ströhle Andreas, Schumann Gunter, Klingberg Torkel
Abstract excerpt
Motivation is important for learning and cognition. Although dopaminergic (D2) transmission in the ventral striatum (VS) is associated with motivation, learning, and cognition are more strongly associated with function of the dorsal striatum, including activation in the caudate nucleus. A recent study found an interaction between intrinsic motivation and the DRD2/ANKK1 polymorphism (rs1800497), suggesting that...
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