Article
CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection.
Journal of hepatology - 1 Aug 2010
Hoare Matthew, Gelson William T H, Das Abhi, Fletcher Jean M, Davies Susan E, Curran Martin D, Vowler Sarah L, Maini Mala K, Akbar Arne N, Alexander Graeme J M
Abstract excerpt
BACKGROUND & AIMS: Increasing age is associated with impaired immune function and in chronic HCV infection specifically, with progressive fibrosis, liver failure, HCC and impaired responses to antiviral therapy. T-lymphocyte telomere length declines with age. We hypothesised that shorter T-lymphocyte telomere length would be associated with poor clinical outcome in HCV infection. METHODS: Circulating T-lymphocyte...
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