Article
MxA transcripts with distinct first exons and modulation of gene expression levels by single-nucleotide polymorphisms in human bronchial epithelial cells.
Immunogenetics - 1 Feb 2013
Noguchi Satoshi, Hijikata Minako, Hamano Emi, Matsushita Ikumi, Ito Hideyuki, Ohashi Jun, Nagase Takahide, Keicho Naoto
Abstract excerpt
Myxovirus resistance A (MxA) is a major interferon (IFN)-inducible antiviral protein. Promoter single-nucleotide polymorphisms (SNPs) of MxA near the IFN-stimulated response element (ISRE) have been frequently associated with various viral diseases, including emerging respiratory infections. We investigated the expression profile of MxA transcripts with distinct first exons in human bronchial epithelial cells....
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