Article
Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.
Journal of hepatology - 1 Nov 2005
Katoh Hiroto, Shibata Tatsuhiro, Kokubu Akiko, Ojima Hidenori, Loukopoulos Panayiotis, Kanai Yae, Kosuge Tomoo, Fukayama Masashi, Kondo Tadashi, Sakamoto Michiie, Hosoda Fumie, Ohki Misao, Imoto Issei, Inazawa Johji, Hirohashi Setsuo
Abstract excerpt
BACKGROUND/AIMS: We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma. METHODS: We analyzed 87 hepatocellular carcinomas by array-based comparative genomic hybridization with an array containing 800 bacterial artificial chromosome clones. RESULTS: Frequent (>30%) chromosomal losses on 1p36.1, 4q21-25, 4q34-35.1, 8p23.3b-11.1, 13q14.1-14.3,...
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