Article
Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.
American journal of physiology. Cell physiology - 1 Jun 2010
Mistry Abinash C, Mallick Rickta, Klein Janet D, Sands Jeff M, Fröhlich Otto
Abstract excerpt
Of the three major protein variants produced by the UT-A gene (UT-A1, UT-A2, and UT-A3) UT-A1 is the largest. It contains UT-A3 as its NH(2)-terminal half and UT-A2 as its COOH-terminal half. When being part of UT-A1, UT-A3 and UT-A2 are joined by a segment, Lp, whose central part, Lc, is not part of UT-A3 or UT-A2 but is present only in UT-A1. Lc contains the phosphorylation sites S486 and S499 that are involved...
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