Article
Deglycosylation of HIV-1 AE Gp140 enhances the capacity to elicit neutralizing antibodies against the heterologous HIV-1 clade.
AIDS research and human retroviruses - 1 May 2010
Zhang Congyou, Wan Yanmin, Shi Jijing, Zhou Mingzhe, Meng Zhefeng, Yuan Songhua, Qiu Chao, Zhang Xiaoyan, Xu Xuemei, Liu Chaoqi, Xu Jianqing
Abstract excerpt
The aim of this study was to test whether deglycosylation of an HIV-1 AE recombinant-derived gp140 could enhance the induction of neutralizing antibodies. N-to-Q mutations were introduced in the V1/V2 (m157/161) or V4 (m382/388) loops by using overlapping PCR. BALB/c mice were inoculated with different DNA vaccines at weeks 0, 2, 4, and 7. The Elispot assay was used to quantify Env-specific T-cell immunity, and...
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