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Genetic and Neutralization Properties of HIV-1 env Clones From Subtype B/BC/AE Infections in China

10 Mar 2008

Abstract excerpt

BACKGROUND: As HIV vaccines move into preclinical and clinical trials in China, pseudovirion-based neutralization assays, especially those using env genes of Chinese origin, are widely required to evaluate the ability of HIV vaccines to induce neutralizing antibody (nAb) responses. MATERIALS AND METHODS: Functional gp160 genes from plasma samples from Chinese HIV-infected patients were cloned and sequenced and...

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PMID: 18209676
DOI: 10.1097/qai.0b013e3181663967

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