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Cancer Reduces Transcriptome Specialization

3 May 2010

Abstract excerpt

A central goal of cancer biology is to understand how cells from this family of genetic diseases undergo specific morphological and physiological changes and regress to a de-regulated state of the cell cycle. The fact that tumors are unable to perform most of the specific functions of the original tissue led us to hypothesize that the degree of specialization of the transcriptome of cancerous tissues must be less...

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PMID: 20454660
DOI: 10.1371/journal.pone.0010398

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