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Article

Abacavir and didanosine induce the interaction between human leukocytes and endothelial cells through Mac-1 upregulation

6 May 2010

Abstract excerpt

OBJECTIVE: Abacavir and didanosine are nucleoside reverse transcriptase inhibitors (NRTI) widely used in therapy for HIV-infection but which have been linked to cardiovascular complications. The objective of this study was to analyze the effects of clinically relevant doses of abacavir and didanosine on human leukocyte-endothelium interactions and to compare them with those of other NRTIs. DESIGN AND METHODS: The...

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PMID: 20453628
DOI: 10.1097/qad.0b013e32833a2b02

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