Article
The effect of alendronate on cytokine production, adhesion molecule expression, and transendothelial migration of human peripheral blood mononuclear cells.
Calcified tissue international - 1 Oct 1998
Pietschmann P, Stohlawetz P, Brosch S, Steiner G, Smolen J S, Peterlik M
Abstract excerpt
Since both osteoclasts and macrophages belong to the mononuclear phagocytic system it is conceivable that bisphosphonates not only affect bone metabolism but also inflammatory responses. The migration of mononuclear cells into perivascular tissue is a central event in inflammatory reactions. We s...
Topics
- Alendronate
- Antigens, CD
- Cell Adhesion Molecules
- Cell Communication
- Cell Movement
- Cytokines
- Diphosphonates
- Endothelium
- Flow Cytometry
- Humans
- Integrin alpha4
- Integrin alpha4beta1
- Integrin beta1
- Integrins
- Intercellular Adhesion Molecule-1
- Interferon-gamma
- Interleukin-1
- Leukocytes, Mononuclear