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Article

Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds.

Biochimica et biophysica acta - 1 Sept 2010

Lisk Godfrey, Pain Margaret, Sellers Morgan, Gurnev Philip A, Pillai Ajay D, Bezrukov Sergey M, Desai Sanjay A

Abstract excerpt

Erythrocytes infected with malaria parasites have increased permeability to various solutes. These changes may be mediated by an unusual small conductance ion channel known as the plasmodial surface anion channel (PSAC). While channel activity benefits the parasite by permitting nutrient acquisition, it can also be detrimental because water-soluble antimalarials may more readily access their parasite targets via...

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Identifiers

PMID: 20451492
DOI: 10.1016/j.bbamem.2010.04.013
PMCID: PMC2906662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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