Article
Complex inheritance of the plasmodial surface anion channel in a Plasmodium falciparum genetic cross.
Molecular microbiology - 1 Apr 2009
Alkhalil Abdulnaser, Pillai Ajay D, Bokhari Abdullah A B, Vaidya Akhil B, Desai Sanjay A
Abstract excerpt
Human erythrocytes infected with the malaria parasite Plasmodium falciparum have increased permeabilities to many solutes. The plasmodial surface anion channel (PSAC) may mediate these changes. Despite good understanding of the biochemical and biophysical properties, the genetic basis of PSAC activity remains unknown. Functional polymorphisms in laboratory isolates and two mutants generated by in vitro selection...
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