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Article

Dihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant.

Biochemistry - 15 Jun 2010

Lewis Ryan W, Mabry John, Polisar Jason G, Eagen Kyle P, Ganem Bruce, Hess George P

Abstract excerpt

Gamma-aminobutyric acid type A receptors (GABA(A) receptors) are ligand-gated chloride channels that play a central role in signal transmission within the mammalian central nervous system. Compounds that modulate specific GABA(A) receptor subtypes containing the delta-subunit are scarce but would...

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Identifiers

PMID: 20450160
DOI: 10.1021/bi100119t
PMCID: PMC5026497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20450160-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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